I can honestly say that no comic series has ever made me laugh harder than Barry Ween. Writer/Artist Judd Winick packs each volume (to date, there are four) with bizarre plots, madcap sight gags, pop-culture references, and lowbrow humor (the latter comes primarily from Barry's sidekick, Jeremy). There is also the occasional poignant moment (usually involving Barry's classmate Sara) that never feels out of place, even among all of the mayhem.
Recommended For: Fans of Kevin Smith films, South Park, Dexter's Laboratory, and/or Family Guy; fans of off-color humor in general.
Not Recommended For: people who are offended by profanity.